{"id":1780,"date":"2023-07-19T11:55:00","date_gmt":"2023-07-19T08:55:00","guid":{"rendered":"https:\/\/probatio.com.tr\/testicaret\/?p=1780"},"modified":"2023-07-26T05:00:12","modified_gmt":"2023-07-26T02:00:12","slug":"egeli-arastirmacilar-koyun-ve-keciler-uzerinden-covid-19-salginini-inceleyecek","status":"publish","type":"post","link":"https:\/\/probatio.com.tr\/testicaret\/2023\/07\/19\/egeli-arastirmacilar-koyun-ve-keciler-uzerinden-covid-19-salginini-inceleyecek\/","title":{"rendered":"Egeli ara\u015ft\u0131rmac\u0131lar koyun ve ke\u00e7iler \u00fczerinden Covid-19 salg\u0131n\u0131n\u0131 inceleyecek"},"content":{"rendered":"\n
\"Ege<\/figure><\/a><\/div>\n\n\n\n

Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Cemal \u00dcn\u2019\u00fcn y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cT\u00fcrkiye\u2019de yeti\u015ftiricili\u011fi yap\u0131lan koyun ve ke\u00e7i \u0131rklar\u0131nda ACE2 resept\u00f6r varyasyonlar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ve Cov\u0131d-19\u2019u bula\u015ft\u0131r\u0131c\u0131l\u0131klar\u0131 a\u00e7\u0131s\u0131ndan SARS-CoV-2 ile etkile\u015fiminin incelenmesi\u201d ba\u015fl\u0131kl\u0131 projesi ile \u201cT\u00dcB\u0130TAK 1001 \u2013 Bilimsel ve Teknolojik Ara\u015ft\u0131rma Projelerini Destekleme Program\u0131\u201d kapsam\u0131nda desteklenmeye uygun bulundu.<\/p>\n\n\n\n

Prof. Dr. \u00dcn ve ekibi proje kapsam\u0131nda Cov\u0131d-19\u2019la m\u00fccadele i\u00e7in bir koyun, ke\u00e7i \u00fcretim modeli geli\u015ftirerek belirli \u0131rklar\u0131n salg\u0131n d\u00f6neminde izole edilmesi veya \u00fcretiminin k\u0131s\u0131tlanmas\u0131n\u0131n yan\u0131nda belirli \u0131rklar\u0131nda da \u00fcretiminin artt\u0131r\u0131lmas\u0131 i\u00e7in salg\u0131n ko\u015fullar\u0131na yard\u0131mc\u0131 bir \u00fcretim platformu hayata ge\u00e7irecek.<\/p>\n\n\n\n

\n\n\n\n
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Ke\u00e7i ve koyunlar hastal\u0131\u011f\u0131 yaymada risk grubunda<\/p>\n<\/blockquote>\n\n\n\n

\u00c7al\u0131\u015fmada ke\u00e7i ve koyunlar\u0131n hastal\u0131\u011f\u0131 yayma konusunda riskler ta\u015f\u0131d\u0131\u011f\u0131n\u0131 ifade eden Prof. Dr. \u00dcn, \u201cKe\u00e7i ve koyunlar\u0131n hastal\u0131\u011f\u0131 yayma ve ba\u015fka varyantlar\u0131 olu\u015fturmalar\u0131 riskini tespit a\u00e7\u0131s\u0131ndan \u00f6nemli eksiklikleri mevcuttur. Birinci eksiklik bu \u00e7al\u0131\u015fmalar\u0131n Wuhan izolat\u0131 genomuna yak\u0131n genomik yap\u0131ya sahip izolatlar ile ger\u00e7ekle\u015ftirilmi\u015f olmas\u0131d\u0131r. Bug\u00fcn art\u0131k Wuhan izolat\u0131na g\u00f6re Delta ve Omicron varyantlar\u0131 \u00e7ok daha y\u00fcksek s\u0131kl\u0131kta insanlarda saptanmaktad\u0131r. Bu sebeple bu \u00e7al\u0131\u015fmalar\u0131n tekrar g\u00f6zden ge\u00e7irilerek insanlarla yak\u0131n ili\u015fki i\u00e7erisinde olan hayvanlar\u0131n yeni varyantlar i\u00e7in konak stat\u00fcs\u00fcn\u00fcn yeniden de\u011ferlendirilmesi gerekmektedir. <\/p>\n\n\n\n

\u0130kinci eksiklik ise, insan da baz\u0131 ACE2 resept\u00f6r varyasyonlar\u0131n\u0131n SARS-CoV-2\u2019ye kar\u015f\u0131 duyarl\u0131l\u0131k ile ili\u015fkisi oldu\u011fu bilinmesine ra\u011fmen koyun ve ke\u00e7i gibi hayvanlarda ACE2 resept\u00f6r \u00fczerindeki varyasyonlar \u00e7ok iyi bilinmedi\u011finden varyasyonlar\u0131n spike protein ile ili\u015fkisi yan\u0131nda varyasyonlar\u0131n hangi SARS-CoV-2 varyant\u0131 ile daha iyi veya daha az etkile\u015fim g\u00f6sterece\u011fi hakk\u0131nda da bir verinin bulunmamas\u0131d\u0131r. \u00dc\u00e7\u00fcnc\u00fc eksiklik ise koyun ve ke\u00e7i \u0131rklar\u0131 aras\u0131ndaki SARS-CoV-2 RNA pozitifli\u011fi prevalans\u0131 yan\u0131nda seroprevalans de\u011ferleri de bilinmemektedir. Projede bu eksik konular\u0131n ele al\u0131nmas\u0131 hedefledik\u201d dedi.<\/p>\n\n\n\n

\n

31 farkl\u0131 koyun ve 7 farkl\u0131 ke\u00e7i \u0131rk\u0131 \u00fczerinde \u00e7al\u0131\u015f\u0131lacak<\/p>\n<\/blockquote>\n\n\n\n

Projede T\u00fcrkiye\u2019de temsiliyet oran\u0131 y\u00fcksek olan 31 farkl\u0131 koyun ve 7 farkl\u0131 ke\u00e7i \u0131rk\u0131 \u00fczerinde \u00e7al\u0131\u015fmalar y\u00fcr\u00fctt\u00fcklerini belirten Prof. Dr. \u00dcn, \u201cBu proje ile son zamanlarda ortaya \u00e7\u0131kan ve olduk\u00e7a bula\u015f\u0131c\u0131 bir varyant olarak bildirilen Omicron varyant\u0131 ile koyun ve ke\u00e7i ACE2 varyantlar\u0131 aras\u0131nda biyoinformatik olarak elde edilen g\u00fc\u00e7l\u00fc ve d\u00fc\u015f\u00fck etkile\u015fim sonu\u00e7lar\u0131n\u0131n in vitro test edilmesi, hayvanlardan toplanan s\u00fcr\u00fcnt\u00fc \u00f6rneklerinde SARS-CoV-2 RNA\u2019s\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131, serum \u00f6rneklerinde ise anti-SARS-CoV-2 IgG antikorlar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131n\u0131 ama\u00e7l\u0131yoruz\u201d dedi. <\/p>\n\n\n\n

Projenin \u00e7\u0131kt\u0131lar\u0131ndan da bahseden Prof. Dr. \u00dcn, \u201cT\u00fcm bu bulgular de\u011ferlendirildi\u011finde tek sa\u011fl\u0131k konsepti alt\u0131nda SARS-CoV-2 i\u00e7in konak olabilme potansiyeli olan koyun ve ke\u00e7iler \u0131rk d\u00fczeyinde belirlenecek. D\u00fcnya da ilk kez \u0131rk baz\u0131nda koyun ve ke\u00e7ilerde ACE2 resept\u00f6r sekans verileri ve varyasyonlar\u0131 elde edilecek. ACE2 resept\u00f6r varyantlar\u0131n\u0131n SARS-CoV-2 varyantlar\u0131 ile ba\u011flanma etkile\u015fimleri ortaya \u00e7\u0131kar\u0131lacak. Bu sayede COVID- 19\u2019un uzun y\u0131llar \u00f6nemini korumas\u0131 beklendi\u011finden belirli \u0131rklar\u0131n salg\u0131n d\u00f6neminde izole edilmesi veya \u00fcretiminin k\u0131s\u0131tlanmas\u0131 yan\u0131nda belirli \u0131rklar\u0131nda \u00fcretiminin artt\u0131r\u0131lmas\u0131 i\u00e7in salg\u0131n ko\u015fullar\u0131na yard\u0131mc\u0131 bir \u00fcretim modeli ilk kez geli\u015ftirilecek. Bu model ayr\u0131ca \u00f6n\u00fcm\u00fczdeki 50 y\u0131lda d\u00fcnyam\u0131zda besine ula\u015f\u0131m\u0131n risk alt\u0131nda olaca\u011f\u0131 beklentisinin azalmas\u0131na da katk\u0131 yapacak\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Cemal \u00dcn\u2019\u00fcn y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cT\u00fcrkiye\u2019de yeti\u015ftiricili\u011fi yap\u0131lan koyun ve ke\u00e7i \u0131rklar\u0131nda ACE2 resept\u00f6r varyasyonlar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ve Cov\u0131d-19\u2019u bula\u015ft\u0131r\u0131c\u0131l\u0131klar\u0131 a\u00e7\u0131s\u0131ndan SARS-CoV-2 ile etkile\u015fiminin incelenmesi\u201d ba\u015fl\u0131kl\u0131 projesi ile \u201cT\u00dcB\u0130TAK 1001 \u2013 Bilimsel ve Teknolojik Ara\u015ft\u0131rma Projelerini Destekleme Program\u0131\u201d kapsam\u0131nda desteklenmeye uygun bulundu. Prof. Dr. \u00dcn ve ekibi […]<\/p>\n","protected":false},"author":1,"featured_media":1665,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[64],"tags":[],"class_list":{"0":"post-1780","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-hayvancilik"},"_links":{"self":[{"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/posts\/1780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/comments?post=1780"}],"version-history":[{"count":1,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/posts\/1780\/revisions"}],"predecessor-version":[{"id":1781,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/posts\/1780\/revisions\/1781"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/media\/1665"}],"wp:attachment":[{"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/media?parent=1780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/categories?post=1780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/probatio.com.tr\/testicaret\/wp-json\/wp\/v2\/tags?post=1780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}